2. GPCR/G Protein
  3. Secretin Receptor
  4. Secretin (swine)

Secretin (swine)  (Synonyms: 促胰液素)

目录号: HY-109538 纯度: 99.16%
COA 产品使用指南

摩尔计算器

Secretin (swine)，是一种神经内分泌激素，是第一个被识别的激素，主要由定位于十二指肠黏膜的 S 细胞分泌。Secretin 也是一个由 27 个氨基酸组成的多肽，作用于分泌素受体。Secretin 在所有成熟的肠内分泌细胞亚群中都有表达，并可由脂肪酸促进。Secretin 刺激胰腺水和碳酸氢盐的分泌。Secretin 在器官中发挥多种作用，可用于消化系统、中枢神经系统和能量代谢的研究。

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Custom Peptide Synthesis

Secretin (swine) Chemical Structure

Secretin (swine) Chemical Structure

CAS No. : 17034-35-4

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规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥2250
In-stock
10 mg ￥3600
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Secretin (swine):

Secretin (swine) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism[1][2].

体外研究
(In Vitro)

Secretin (swine) (10-7M, 10-6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling[2].
Secretin (10-7M, 10-6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines[2][3][4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Secretin (swine) 相关抗体:

Immunofluorescence[2]

Cell Line: large murine cholangiocyte lines
Concentration: 10−7M, 10−6 M
Incubation Time: 24 to 72 h and 7 days
Result: Increased the proliferation of cholangiocytes.

Cell Proliferation Assay[2]

Cell Line: human HIBEpiC and large murine cholangiocyte lines
Concentration: 10−7M, 10−6M
Incubation Time: 24 to 72 h and 7 days
Result: Increased the proliferation of non-transfected, vector-transfected and secretin shRNA large cholangiocytes and HiBEpiC compared to the cell lines treated with BSA (basal).
体内研究
(In Vivo)

Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sct+/- mice[2]
Dosage: 2.5 nM/kg
Administration: 2.5 nM/kg, BW/day, osmotic minipumps, for 1 week
Result: Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.
Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct+/- mice.
Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue[2].
分子量

3055.41

Formula

C130H220N44O41
CAS 号
性状

固体

颜色

White to off-white

Sequence

His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
Sequence Shortening

HSDGTFTSELSRLRDSARLQRLLQGLV-NH2
中文名称

促胰液素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 66.67 mg/mL (21.82 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3273 mL 1.6364 mL 3.2729 mL
5 mM 0.0655 mL 0.3273 mL 0.6546 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.16%

COA (278 KB) RP-HPLC (129 KB) MS (191 KB)

产品使用指南 (1538 KB)
参考文献

Secretin (swine) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3273 mL 1.6364 mL 3.2729 mL 8.1822 mL
5 mM 0.0655 mL 0.3273 mL 0.6546 mL 1.6364 mL
10 mM 0.0327 mL 0.1636 mL 0.3273 mL 0.8182 mL
15 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.5455 mL
20 mM 0.0164 mL 0.0818 mL 0.1636 mL 0.4091 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Secretin (swine)17034-35-4促胰液素Secretin ReceptorSCTRneuroendocrine hormoneS cellspeptidesecretin receptorsenteroendocrine celldigestive systemcentral nervous systemenergy metabolismInhibitorinhibitorinhibit

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目录号：
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