Secretin Receptor (分泌素受体)

Secretin receptor (SCTR) is a G protein-coupled receptor (GPCR) which binds secretin. The secretin receptor has a 427-amino acid sequence and a molecular weight of 48,696 Da. The secretin receptor is related structurally to the receptors for VIP, parathyroid hormone (PTH), and calcitonin. Secretin receptors are expressed in the basolateral domain of several cell types. Secretin is a member of the secretin-glucagon family and is secreted by S cells of the duodenum in the small intestine. In addition to regulating the pH of the duodenal content by the control of gastric acid secretion, secretin regulates the secretion of bicarbonate ions into the duodenum from the epithelia lining the pancreatic and biliary ducts. Secretin has also been considered as a neuropeptide hormone since it is also expressed in the central nervous system (CNS). Recent evidence has indicated that secretin has pleiotropic effects in several organ systems (including the biliary epithelium) and has been termed a neuroendocrine hormone.