Secukinumab  (Synonyms: 司库奇尤单抗; AIN457)

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

Secukinumab 是一种全人源单克隆抗体，可选择性结合并中和白细胞介素 17A^[2]。
Secukinumab (1 nM、10 nM 和 100 nM) 可抑制 IL17A 和 IL17A/TNF a-诱导人星形胶质细胞中 IL6 蛋白水平的增加^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1229022-83-6

液体

Colorless to light yellow

苏金单抗；司库奇尤单抗

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

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  Immobilized IL-17A Protein, Human (HEK293, His, HY-P70527) can bind Secukinumab. The EC₅₀ for this effect is 16.2 ng/mL.

• [1]. Shirley M, et al. Secukinumab: A Review in Psoriatic Arthritis. Drugs. 2016;76(11):1135-1145.  [Content Brief]

  [2]. Reich K, et al. Secukinumab dosing optimization in patients with moderate-to-severe plaque psoriasis: results from the randomized, open-label OPTIMISE study. Br J Dermatol. 2020;182(2):304-315.  [Content Brief]

  [3]. Elain G, et al. The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes. Glia. 2014;62(5):725-735.  [Content Brief]