2. Apoptosis MAPK/ERK Pathway
  3. MAP3K Apoptosis
  4. Selonsertib hydrochloride

Selonsertib hydrochloride  (Synonyms: GS-4997 hydrochloride)

目录号: HY-18938A
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摩尔计算器

Selonsertib hydrochloride (GS-4997 hydrochloride) 是一种口服生物可利用的酶抑制剂，具有潜在的抗炎、抗肿瘤和抗纤维化活性。Selonsertib hydrochloride 通过与ASK1的催化激酶结构域结合，阻止其磷酸化和激活。Selonsertib hydrochloride 防止炎症细胞因子的产生，降低与纤维化相关的基因表达。Selonsertib hydrochloride 抑制过度的细胞凋亡并限制细胞增殖。

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Selonsertib hydrochloride Chemical Structure

Selonsertib hydrochloride Chemical Structure

CAS No. : 1448428-05-4

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Selonsertib hydrochloride 的其他形式现货产品:

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Selonsertib hydrochloride 相关抗体

Top Publications Citing Use of Products

    Selonsertib hydrochloride purchased from MCE. Usage Cited in: Phytother Res. 2022 Nov 24.  [Abstract]

    Selonsertib (5 µM) alleviates TMAO-induced morphological changes and improve cellular viability in RTEC cells.

    查看 MAP3K 亚型特异性产品:

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    MAP3K7/TAK1 MAP3K8 ASK2 MAP3K5/ASK1

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Selonsertib hydrochloride (GS-4997 hydrochloride) is an orally bioavailable enzyme inhibitor with potential anti-inflammatory, anti-tumor and anti-fibrotic activities. Selonsertib hydrochloride blocks ASK1 phosphorylation and activation by binding to the catalytic kinase domain. Selonsertib hydrochloride prevents the production of inflammatory cytokines and reduces the expression of genes associated with fibrosis. Selonsertib hydrochloride inhibits excessive apoptosis and limits cell proliferation[1].

    分子量

    481.95

    Formula

    C24H25ClFN7O
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Selonsertib hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Selonsertib1448428-05-4GS-4997GS4997GS 4997MAP3KApoptosisMAP kinase kinase kinase, MEKK, MAPKKKInhibitorinhibitorinhibit

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