2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Caspase Reactive Oxygen Species Apoptosis
  4. SHetA2

SHetA2 是杂环类视黄酸衍生物，对癌细胞具有细胞毒性，IC50 为 0.37–4.6 μM。SHetA2 调节癌细胞分化，通过线粒体内在途径诱导细胞凋亡 (apoptosis)，在 G2 期阻滞细胞周期。SHetA2 在小鼠体内具有抗肿瘤活性和良好的药代动力学特征。SHetA2具有口服活性。

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SHetA2 Chemical Structure

SHetA2 Chemical Structure

CAS No. : 361483-66-1

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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SHetA2 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHetA2 is a derivative of heteroarotinoid, that exhibits cytotoxicity in cancer cells with IC50 of 0.37–4.6 μM. SHetA2 regulates cancer cells differentiation, induces apoptosis through the intrinsic mitochondrial pathway, and arrest cell cycle at G2 phase. SHetA2 exhibits good pharmacokinetic characteristics and antitumor efficacy in mice. SHetA2 is orally active[1][2].

分子量

401.55

Formula

C20H23N3O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHetA2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHetA2361483-66-1SHetA 2SHetA-2CaspaseReactive Oxygen SpeciesApoptosisCD2F1 mouseOVCAR3orally activeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-125677
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