Sinapultide 

Sinapultide is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide can be used for synthetic phospholipids surfactants improvement^[1].

Sinapultide microbubble preparation (2 μg/mL, 5 μg/mL; 24 h) combined with ultrasound (0.5 MHz, 40 s) could promote the function recovery of injured AT II cells effectively via affecting TNF-α and IL-6 levels^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sinapultide-loaded microbubbles (MBs) (0.1 mg; nasal delivery; collected at 3, 6, 12 and 24 hours after LPS) improves pulmonary edema in lung injury and increases lung W/D weight in LPS-induced ALI mice^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2469.40

C₁₂₆H₂₃₈N₂₆O₂₂

138531-07-4

固体

White to off-white

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Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Braide-Moncoeur O, et al. Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders. Curr Opin Chem Biol. 2016 Jun;32:22-8.  [Content Brief]

  [2]. Liu D, et al. Sinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Drug Des Devel Ther. 2020 Dec 22;14:5611-5622.  [Content Brief]