2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Sintilimab (Anti-PD-1)

Sintilimab (Anti-PD-1)  (Synonyms: IBI308 (Anti-PD-1))

目录号: HY-P99048A
技术支持

Sintilimab (Anti-PD-1) (IBI308 (Anti-PD-1)) 是一种安全有效的人源的 IgG4 单克隆抗体，与 PD-1 结合，其 KD 值为 74 pM。Sintilimab (Anti-PD-1) 阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用，从而有助于恢复内源性抗肿瘤 T 细胞反应。Sintilimab (Anti-PD-1) 联合益生元抑制肺腺癌小鼠肿瘤体积，调节免疫细胞亚群平衡。Sintilimab (Anti-PD-1) 可用于经典霍奇金淋巴瘤、非小细胞肺癌和食管癌的研究

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Sintilimab (Anti-PD-1) Chemical Structure

Sintilimab (Anti-PD-1) Chemical Structure

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Sintilimab (Anti-PD-1) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sintilimab (Anti-PD-1) (IBI308 (Anti-PD-1)) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab (Anti-PD-1) blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab (Anti-PD-1) combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab (Anti-PD-1) can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer[1][2][3][4][5].

体外研究
(In Vitro)

Sintilimab (150 ng/μL, 12 小时) 在人外周血单核细胞 (PBMCs) 中显示出高水平的 PD-1 结合能力和优越的 T 细胞激活特性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sintilimab (Anti-PD-1) 相关抗体:
体内研究
(In Vivo)

Sintilimab (0.1 mg/kg, 1 mg/kg 和 10 mg/kg，腹腔注射, 单次剂量, 1, 8, 12, 5 天) 在人源化小鼠模型中显示出对 NCI-H292 肿瘤的抗肿瘤作用[2]。
Sintilimab (1 mg/kg, 3 mg/kg 和 10 mg/kg, 皮下注射, 单剂量) 在 NCI-H292 肿瘤携带的 NOG 小鼠中对 PD-1 分子表现出很高的亲和力[2]。
Sintilimab (20 mg/kg, 腹腔注射, 2 天一次，连续 21 天) 联合益生元抑制肺腺癌移植瘤体积，减轻肝、肾损伤[4]。

Sintilimab (10 mg/kg, 静脉注射，单剂量) 在 hPD-1 敲入小鼠中的药代动力学参数[2]

Parameter AUC0-4 (h·μg/mL) AUCinf (h·μg/mL) CL (mL/h) Cmax (μg/mL) T1/2 (h) Vss (mL)
Sintilimab 6597.888 7846.554 0.025 218.519 35.623 1.262

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
中文名称

信迪利 (Anti-PD-1)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sintilimab (Anti-PD-1) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sintilimab (Anti-PD-1)IBI308 (Anti-PD-1)信迪利 (Anti-PD-1)PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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