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  4. SJ000025081

SJ000025081 是一种二氢吡啶，可作为一种抗疟剂 (antimalarial agent)。SJ000025081 在小鼠疟疾模型中明显抑制 P. yoelii 感染的寄生虫血症。

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SJ000025081 Chemical Structure

SJ000025081 Chemical Structure

CAS No. : 421571-66-6

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SJ000025081 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii[1].

体内研究
(In Vivo)

SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 µg/ml, 0.0113 µg/ml per mg/ml, 1.0 h and 0.224 µg.h/ml, respectively[1].
SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with P. yoelii. SJ000025081 can result in a 90% suppression of the parasitemia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks old CD-1 mice[1]
Dosage: 5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration: Intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days
Result: Was active in a malaria murine model infected with P. yoelii.
分子量

479.54

Formula

C28H30FNO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SJ000025081 相关分类

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Keywords:

SJ000025081421571-66-6SJ 000025081SJ-000025081ParasiteantimalarialparasitemiamalariaP. yoeliidihydropyridinePlasmodium falciparumInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-136448
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