2. PROTAC
  3. PROTACs
  4. SMD-1087

SMD-1087 是一种选择性靶向 SMARCA2 的 PROTAC (DC50=8 nM，Dmax=89%)，对 SMARCA4 的 DC50>1 μM。SMD-1087 由 E3 连接酶配体 (S,R,S)-AHPC-Me (blue part) (HY-112078)，靶蛋白配体 SMI-1074 (red part) (HY-170817)，和 PROTAC linker (1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate (black part) (HY-W890392) 组成。其中，它的 靶蛋白配体+Linker 部分对应 SMARCA2 Ligand-Linker Conjugate-1 (HY-170829)。

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SMD-1087 Chemical Structure

SMD-1087 Chemical Structure

CAS No. : 3033586-04-5

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SMD-1087 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMD-1087 is a PROTAC that selectively targets SMARCA2 (DC50=8 nM, Dmax=89%) and SMARCA4 with a DC50 of 1 μM. SMD-1087 consists of the E3 ligase ligand (S,R,S)-AHPC-Me (blue part) (HY-112078), the target protein ligand SMI-1074 (red part) (HY-170817), and the PROTAC linker (1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate (black part) (HY-W890392). Among them, its target protein ligand + Linker part corresponds to SMARCA2 Ligand-Linker Conjugate-1 (HY-170829)[1].

IC50 & Target

SMARCA2[1]
分子量

986.70

Formula

C56H68ClN7O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMD-1087 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMD-10873033586-04-5SMD1087SMD 1087PROTACsInhibitorinhibitorinhibit

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目录号：
HY-170828
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