2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. SOS1/EGFR-IN-2

SOS1/EGFR-IN-2 (Compound 4) 是 SOS1 和 EGFR 的双重抑制剂，其IC50 分别为 8.3 和 14.6 nM。SOS1/EGFR-IN-2 对携带多种 KRAS 突变体的癌细胞具有显著的抗增殖作用。

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SOS1/EGFR-IN-2 Chemical Structure

SOS1/EGFR-IN-2 Chemical Structure

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SOS1/EGFR-IN-2 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SOS1/EGFR-IN-2 (Compound 4) is a SOS1 and EGFR dual inhibitor with IC50s of 8.3 and 14.6 nM, respectively. SOS1/EGFR-IN-2 exhibits significant antiproliferative effect on the cancer cells haboring various KRAS mutants[1].

分子量

490.52

Formula

C25H29F3N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SOS1/EGFR-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1/EGFR-IN-2EGFREpidermal growth factor receptorErbB-1HER1son of sevenless 1epidermal growth factor receptorKRAS mutantsInhibitorinhibitorinhibit

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产品名称：
SOS1/EGFR-IN-2
目录号：
HY-168514
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