2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Adrenergic Receptor Potassium Channel
  4. Sotalol

Sotalol  (Synonyms: 索他洛尔)

目录号: HY-103196
产品使用指南

摩尔计算器

Sotalol 是一种口服有效，非选择性 β-肾上腺素受体阻断剂。Sotalol 具有抗心律失常作用，可用于小儿心律失常的研究。Sotalol 阻断 β 受体和钾 KCNH2 通道，具有抗抗癫痫作用。

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Sotalol Chemical Structure

Sotalol Chemical Structure

CAS No. : 3930-20-9

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规格 是否有货
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Sotalol 的其他形式现货产品:

Customer Review

Other Forms of Sotalol:

Sotalol 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent[1][2][3].

IC50 & Target[1]

β-adrenoceptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
> 100 μM
Compound: Sotalol
Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
CHO IC50
193.3 μM
Compound: sotalol
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
[PMID: 23812503]
HEK293 IC50
1023 μM
Compound: Sotalol
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
[PMID: 22761000]
SK-MEL-28 IC50
> 100 μM
Compound: Sotalol
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
SK-MEL-5 IC50
> 100 μM
Compound: Sotalol
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
体内研究
(In Vivo)

Sotalol is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-25 g female Swiss mice[3]
Dosage: 100 mg/kg
Administration: Administered intraperitoneally
Result: Significantly decreased the brain concentrations of Lamotrigine and increased those of Oxcarbazepine and Topiramate.
分子量

272.36

Formula

C12H20N2O3S
CAS 号
中文名称

索他洛尔；甲磺胺心定；索它洛尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sotalol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sotalol3930-20-9索他洛尔甲磺胺心定索它洛尔Adrenergic ReceptorPotassium ChannelBeta ReceptorKcsAantiepilepticPharmacodynamic,Antiarrhythmicpediatricarrhythmiasβ-receptorpotassiumKCNH2channelInhibitorinhibitorinhibit

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