2. Immunology/Inflammation
  3. STING
  4. SR-717 free acid

SR-717 free acid 是一种非核苷类 STING 激动剂，在 ISG-THP1 (WT) 和 ISG-THP1 cGAS KO (cGAS KO) 细胞中的 EC50 分别为 2.1 μM 和 2.2 μM。SR-717 free acid 是一种稳定的环鸟苷单磷酸腺苷单磷酸 (cGAMP) 类似物。具有抗肿瘤活性。

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SR-717 free acid Chemical Structure

SR-717 free acid Chemical Structure

CAS No. : 2375420-34-9

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SR-717 free acid 的其他形式现货产品:

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SR-717 free acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1].

体外研究
(In Vitro)

SR-717 activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity[1].
SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SR-717 free acid 相关抗体:
体内研究
(In Vivo)

SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice[1].
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT or Stinggt/gt mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneally; once-per-day for 1 week
Result: Maximally inhibited tumor growth.
分子量

345.26

Formula

C15H9F2N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SR-717 free acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-7172375420-34-9SR717SR 717STINGStimulator of Interferon GenesTMEM173MITAERISMPYSISG-THP1cGAMPmimeticantitumorimmunityPD-L1THP1Inhibitorinhibitorinhibit

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SR-717 free acid
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