2. Epigenetics
  3. Histone Methyltransferase
  4. ssK36

ssK36 是组蛋白甲基转移酶 (SET) 结构域蛋白 2 (SETD2) 的超底物肽，ssK36 是针对 SETD2 蛋白设计的，这是一种特定的 PKMT，它在人体细胞中负责将甲基团添加到组蛋白 H3 的第 36 个赖氨酸残基上 (H3K36)，形成 H3K36me3。ssK36 能够被 SETD2 以比自然底物 H3K36 快 100 倍以上的速率甲基化。ssK36 可用于研究 PKMTs 的催化机制，特别是底物特异性和催化效率。

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Custom Peptide Synthesis

ssK36 Chemical Structure

ssK36 Chemical Structure

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ssK36 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ssK36 is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2), and ssK36 is designed for the SETD2 protein, a specific PKMT. It is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency[1].

分子量

1771.04

Formula

C79H127N29O18
Sequence

Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro
Sequence Shortening

APRFGGVKRPNRYRP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ssK36 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ssK36ssK 36ssK-36Histone MethyltransferaseSETD2methylationcatalytic efficiencyH2K36specific substrateInhibitorinhibitorinhibit

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目录号：
HY-P10463
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