2. JAK/STAT Signaling Stem Cell/Wnt PROTAC
  3. STAT PROTACs
  4. STAT3 degrader-2

STAT3 degrader-2 是一种基于 PROTAC 的 STAT3 降解剂。 STAT3 degrader-2 可以降低总 STAT3 蛋白的水平。 STAT3 degrader-2 可用于癌症等疾病的研究。

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STAT3 degrader-2 Chemical Structure

STAT3 degrader-2 Chemical Structure

CAS No. : 2497583-03-4

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STAT3 degrader-2 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases[1]. STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SU-DHL-1 IC50
2.6 μM
Compound: SD-91; 2
Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay
Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay
[PMID: 34141084]
体外研究
(In Vitro)

STAT3 degrader-2 (Compound 92) (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM; 3 h) 降低急性白血病 Molm-16 细胞中的总 STAT3 蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3 degrader-2 相关抗体:

Western Blot Analysis[1]

Cell Line: Acute leukemia Molm-16 cells
Concentration: 0.2 μM, 1 μM; 30 nM, 100 nM, 300 nM
Incubation Time: 3 h; 3 h; 6 h, 24 h, 48 h
Result: Degraded the level of total STAT3 protein in acute leukemia Molm-16 cells.
体内研究
(In Vivo)

STAT3 degrader-2 (Compound 92) (i.v.; 50 mg/kg; 6 h, 24 h, 48 h) 降低急性白血病 Molm-16 肿瘤和 SU-DHL-1 中总 STAT3 蛋白和磷酸化 STAT3 (Y705) 蛋白的水平小鼠肿瘤[1]。
STAT3 degrader-2 (i.v.; 25, 50 mg/kg; qw) 对小鼠的 Molm-16 异种移植肿瘤显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 25, 50 mg/kg
Administration: i.v.; qw
Result: Showed antitumor activity in Molm-16 and SU-DHL-1 xenograft mice.
分子量

1136.15

Formula

C59H62N9O13P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3 degrader-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3 degrader-22497583-03-4STATPROTACsPROTACSTAT3cancerInhibitorinhibitorinhibit

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