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  2. STING
  3. STING agonist-12

STING agonist-12 

目录号: HY-147010 纯度: 98.26%
COA 产品使用指南

STING agonist-12 (Compound 53) 是一种口服有效的人 STING 激活剂,EC50 为 185 nM。

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STING agonist-12 Chemical Structure

STING agonist-12 Chemical Structure

CAS No. : 2259624-71-8

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5 mg ¥1000
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10 mg ¥1550
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25 mg ¥3100
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50 mg ¥4800
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].

IC50 & Target

EC50: 185 nM (STING)[1]

体外研究
(In Vitro)

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].
STING agonist-12 is not active at mouse STING[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice (n=3)[1]
Dosage: 5 or 10 mpk
Administration: Lateral tail vein or oral gavage (Pharmacokinetic Analysis)
Result: Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse[1].
Route DOSE
(mpk)
AUC
(ng/mL*h)
T1/2
(h)
Cmax
(ng/mL)
Vd
(mL/kg)
F
(%)
IV 5 1215 1.41 1867 2689 NA
PO 10 2090 NA 1723 NA 86
分子量

490.88

Formula

C25H19ClF4N2O2

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 250 mg/mL (509.29 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0372 mL 10.1858 mL 20.3716 mL
5 mM 0.4074 mL 2.0372 mL 4.0743 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

STING agonist-12 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0372 mL 10.1858 mL 20.3716 mL 50.9289 mL
5 mM 0.4074 mL 2.0372 mL 4.0743 mL 10.1858 mL
10 mM 0.2037 mL 1.0186 mL 2.0372 mL 5.0929 mL
15 mM 0.1358 mL 0.6791 mL 1.3581 mL 3.3953 mL
20 mM 0.1019 mL 0.5093 mL 1.0186 mL 2.5464 mL
25 mM 0.0815 mL 0.4074 mL 0.8149 mL 2.0372 mL
30 mM 0.0679 mL 0.3395 mL 0.6791 mL 1.6976 mL
40 mM 0.0509 mL 0.2546 mL 0.5093 mL 1.2732 mL
50 mM 0.0407 mL 0.2037 mL 0.4074 mL 1.0186 mL
60 mM 0.0340 mL 0.1698 mL 0.3395 mL 0.8488 mL
80 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6366 mL
100 mM 0.0204 mL 0.1019 mL 0.2037 mL 0.5093 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
STING agonist-12
目录号:
HY-147010
需求量: