2. MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation Apoptosis
  3. p38 MAPK ERK JNK Interleukin Related TNF Receptor
  4. Sugiol

Sugiol  (Synonyms: (+)-Sugiol; 10-Deoxoxanthoperol)

目录号: HY-N1195
产品使用指南

摩尔计算器

Sugiol 是一种枞烷二萜，可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性，可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。

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Sugiol Chemical Structure

Sugiol Chemical Structure

CAS No. : 511-05-7

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规格 价格 是否有货 数量
1 mg ￥3040
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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Customer Review

Sugiol 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].

IC50 & Target[1]

ERK1

 

ERK2

 

p38 MAPK

 

JNK1

 

JNK2

 

IL-1β

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 17
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
A549 GI50
79.8 μM
Compound: 13
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
BEAS-2B IC50
> 10 μM
Compound: 17
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
BXPC-3 GI50
36.08 μM
Compound: 13
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
HL-60 IC50
> 10 μM
Compound: 17
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
HL-60 GI50
68.64 μM
Compound: 13
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
K562 IC50
6.7 μM
Compound: Sugiol
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 30684866]
MCF7 IC50
> 10 μM
Compound: 17
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
MIA PaCa-2 IC50
17.9 μM
Compound: 10
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
[PMID: 21775156]
MRC5 GI50
> 100 μM
Compound: 13
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PANC-1 GI50
87.94 μM
Compound: 13
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PC-3 GI50
> 100 μM
Compound: 13
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
SMMC-7721 IC50
> 10 μM
Compound: 17
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
SW480 IC50
> 10 μM
Compound: 17
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
Vero IC50
45.4 μM
Compound: 2
Cytotoxicity against african green monkey Vero cells after 72 hrs
Cytotoxicity against african green monkey Vero cells after 72 hrs
[PMID: 25462275]
体外研究
(In Vitro)

Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。
Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sugiol 相关抗体:

Western Blot Analysis[1]

Cell Line: J774A.1 macrophages cells stimulated with LPS
Concentration: 5 μM, 10 μM, 20 μM, and 30 μM
Incubation Time: 30 min
Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.
分子量

300.44

Formula

C20H28O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sugiol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sugiol511-05-7(+)-Sugiol 10-Deoxoxanthoperolp38 MAPKERKJNKInterleukin RelatedTNF ReceptorExtracellular signal regulated kinasesc-Jun N-terminal kinaseILTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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