2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. T-0156

T-0156 是一种有效的选择性 5 型磷酸二酯酶 (PDE5) 抑制剂。T-0156 以竞争方式特异性抑制 PDE5 对环磷酸鸟苷 (cGMP) 的水解 (IC50=0.23 nM)。T-0156 对 PDE6 具有弱抑制作用 (IC50=56 nM)，对 PDE1、PDE2、PDE3 和 PDE4 具有低效力 (IC50>10 μM)。T-0156 增强一氧化氮 (NO)/cGMP 途径。

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T-0156 Chemical Structure

T-0156 Chemical Structure

CAS No. : 324572-93-2

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Other Forms of T-0156:

T-0156 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway[1].

IC50 & Target[1]

PDE5

0.23 nM (IC50)

PDE1

>100 μM (IC50)

PDE2

>100 μM (IC50)

PDE3

>100 μM (IC50)

PDE4

63 μM (IC50)

PDE6

56 nM (IC50)

体外研究
(In Vitro)

T-0156 at 10 and 100 nM increases cGMP levels, causing relaxation of the tissue in the isolated rabbit corpus cavernosum[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

T-0156 相关抗体:
分子量

620.05

Formula

C31H30ClN5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

T-0156 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-0156324572-93-2T0156T 0156Phosphodiesterase (PDE)phosphodiesterase type 5hydrolysiscGMPnitric oxidePDE1PDE2PDE3PDE4PDE5PDE6Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-105349
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