2. Apoptosis NF-κB
  3. Apoptosis NF-κB
  4. Taraxerol

Taraxerol 是从蒲公英中分离出来的，具有抗炎和抗癌作用。Taraxerol 通过抑制 NF-κB 信号通路来减轻急性炎症。Taraxerol 诱导细胞凋亡 (apoptosis)。

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Taraxerol Chemical Structure

Taraxerol Chemical Structure

CAS No. : 127-22-0

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规格 价格 是否有货 数量
1 mg ￥770
In-stock
5 mg ￥2000
In-stock
10 mg ￥3200
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Taraxerol:

Taraxerol 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2].

IC50 & Target

IC50: apoptosis[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Calu-1 IC50
> 100 μM
Compound: 4
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
HeLa IC50
> 100 μM
Compound: 4
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
K562 IC50
> 100 μM
Compound: 4
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
L6 IC50
> 90 μM
Compound: 13
Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry
Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry
[PMID: 21438586]
Raji IC50
> 100 μM
Compound: 4
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
Vero IC50
> 100 μM
Compound: 4
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
WISH IC50
> 100 μM
Compound: 4
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
体外研究
(In Vitro)

Taraxerol (0-100 μM；24 或 48 小时) 显著降低细胞活力至 95% (20 μM)、89.8% (40 μM)、82.6% (60 μM)、72.9% (80 μM) 和 63.6% (100 μM)。并且该化合物在 20 μM 和 100 μM 浓度下在 48 小时内在 Hela 细胞中的细胞活力分别为 90.7% 和 53.6%[1]。
Taraxerol (80 μM；24或48小时) 以剂量依赖的方式诱导Hela细胞凋亡和细胞死亡。通过 Annexin V/PI 双染法显示，与对照组在早期 (6.5%) 和晚期 (0.5%) 阶段的凋亡细胞数目相比, Taraxerol 可显著诱导细胞凋亡 (早期 24.2% 和晚期 16.2%) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Taraxerol 相关抗体:
体内研究
(In Vivo)

Taraxerol (5 和 10mg/kg；腹腔注射) 减轻角叉菜胶诱导的爪水肿。仅在角叉菜胶处理 4 小时后，5mg/kg Taraxerol 的作用才显著 (p<0.05)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

426.72

Formula

C30H50O
CAS 号
性状

固体

颜色

White to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

THF 中的溶解度 : 10 mg/mL (23.43 mM; 超声助溶)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (287 KB)

产品使用指南 (1538 KB)
参考文献

Taraxerol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
THF 1 mM 2.3435 mL 11.7173 mL 23.4346 mL 58.5864 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL 11.7173 mL
10 mM 0.2343 mL 1.1717 mL 2.3435 mL 5.8586 mL
15 mM 0.1562 mL 0.7812 mL 1.5623 mL 3.9058 mL
20 mM 0.1172 mL 0.5859 mL 1.1717 mL 2.9293 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taraxerol127-22-0ApoptosisNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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目录号：
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