1. Metabolic Enzyme/Protease
  2. FXR
  3. Tauro-β-muricholic acid sodium

Tauro-β-muricholic acid sodium  (Synonyms: T-βMCA sodium)

目录号: HY-135103 纯度: 98.60%
COA 产品使用指南

Tauro-β-muricholic Acid sodium (T-βMCA sodium) 是一种内源性代谢物,是一种竞争性、可逆的 FXR 拮抗剂,其 IC50 值为 40 μM。

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Tauro-β-muricholic acid sodium Chemical Structure

Tauro-β-muricholic acid sodium Chemical Structure

CAS No. : 145022-92-0

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5 mg ¥5000
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Customer Review

Other Forms of Tauro-β-muricholic acid sodium:

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].

IC50 & Target

IC50: 40 μM (FXR)[1]

体外研究
(In Vitro)

T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC50 ~10 μM)[3].
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells[3].
T-βMCA sodium induces proliferation and DNA damage in Lgr5+ cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APCmin/+ mice[3]
Dosage: 400 mg/kg
Administration: Oral gavage; twice a week; for 6 weeks
Result: Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon.
分子量

537.68

Formula

C26H44NNaO7S

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 10 mg/mL (18.60 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8598 mL 9.2992 mL 18.5984 mL
5 mM 0.3720 mL 1.8598 mL 3.7197 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.60%

参考文献

Tauro-β-muricholic acid sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8598 mL 9.2992 mL 18.5984 mL 46.4961 mL
5 mM 0.3720 mL 1.8598 mL 3.7197 mL 9.2992 mL
10 mM 0.1860 mL 0.9299 mL 1.8598 mL 4.6496 mL
15 mM 0.1240 mL 0.6199 mL 1.2399 mL 3.0997 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tauro-β-muricholic acid sodium
目录号:
HY-135103
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