2. Metabolic Enzyme/Protease Apoptosis
  3. FXR Apoptosis
  4. Tauro-β-muricholic acid

Tauro-β-muricholic acid  (Synonyms: TβMCA)

目录号: HY-N9933
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摩尔计算器

Tauro-β-muricholic acid (TβMCA) 是一种三羟基化胆汁酸。Tauro-β-muricholic acid 是一种竞争性、可逆的 FXR 拮抗剂 (IC50 = 40 μM)。Tauro-β-muricholic Acid 具有抗细胞凋亡作用。Tauro-β-muricholic acid 通过维持线粒体膜电位抑制胆汁酸诱导的肝细胞凋亡 (apoptosis)。

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Tauro-β-muricholic acid Chemical Structure

Tauro-β-muricholic acid Chemical Structure

CAS No. : 25696-60-0

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Tauro-β-muricholic acid 的其他形式现货产品:

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Tauro-β-muricholic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].

IC50 & Target

40 μM (FXR)[1]
分子量

515.70

Formula

C26H45NO7S
CAS 号
结构分类
初始来源

rat
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tauro-β-muricholic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tauro-β-muricholic acid25696-60-0TβMCAFXRApoptosisNR1H4bile acidantiapoptoticmitochondrial membrane potentialInhibitorinhibitorinhibit

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