2. GPCR/G Protein
  3. Oxytocin Receptor Vasopressin Receptor
  4. TC OT 39

TC OT 39 是一种合成的催产素类似物，也是催产素受体 (oxytocin receptor) 的选择性激动剂 (OXTR，EC50=180 nM)。TC OT 39 也是 Avprla 加压素受体拮抗剂，Ki 值为 330 nM。TC OT 39 在小鼠模型中表现出镇静的作用。

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TC OT 39 Chemical Structure

TC OT 39 Chemical Structure

CAS No. : 479232-57-0

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规格 价格 是否有货 数量
5 mg ￥4627
3 - 4 周
10 mg 现货 3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

TC OT 39 相关抗体

Top Publications Citing Use of Products

查看 Vasopressin Receptor 亚型特异性产品:

查看所有亚型
V1a Receptor  V1b Receptor  V2 Receptor 

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models[1].

IC50 & Target[1]

Avprla vasopressin receptor

300 nM (Ki)

Oxytocin Receptor

180 nM (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
33 nM
Compound: 1
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
Activity at human oxytocin receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
[PMID: 20104850]
CHO EC50
850 nM
Compound: 1
Activity at human vasopressin V2 receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
Activity at human vasopressin V2 receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
[PMID: 20104850]
体内研究
(In Vivo)

TC OT 39 (50 mg/kg、75 mg/kg；腹腔注射；在 8-9 天内注射 4 次)，在 50 mg/kg 的剂量下，显著减少 C57BL/6J 小鼠的大理石掩埋行为，并在 75 mg/kg 的剂量下显示出明显的镇静作用[1]。
大理石掩埋是基于啮齿动物掩埋物体的自然本能，常用于临床前研究以评估啮齿动物的焦虑样行为[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

600.78

Formula

C32H40N8O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TC OT 39 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC OT 39479232-57-0TC OT39TC OT-39Oxytocin ReceptorVasopressin ReceptorOXTRInhibitorinhibitorinhibit

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目录号：
HY-108678
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