TCF4/β-catenin-IN-1 

TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells^[1].

TCF4/β-catenin-IN-1 (0.4-100 μM, 24 h) 对 HCT-116、A549 和 HepG2 癌细胞系表现出细胞毒活性， IC₅₀ 值分别为 8.52 μM, 5.87 μM and 3.12 μM^[1]。
TCF4/β-catenin-IN-1 (8.52 μM，24小时) 可显著增加 HCT-116 细胞系中 p53 和促凋亡 Bax 表达水平，并下调抗凋亡 Bcl-2 表达水平^[1]。
TCF4/β-catenin-IN-1 (5-20 μM) 以剂量依赖性方式抑制 HCT-116 细胞中的 β-catenin 和 TCF-4 表达^[1]。
TCF4/β-catenin-IN-1 (8.52 μM) 可显著增加 HCT-116 细胞系中的 caspase-3、caspase-8 和 caspase-9 表达水平^[1]。
TCF4/β-catenin-IN-1 可抑制 CYP3A4、CYP1A2、CYP2C19^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

437.41

C₂₃H₁₅N₇O₃

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Deng Y, et al. Design, Synthesis, and Structure-Activity Relationship of 2-(Piperazin-1-yl)quinazolin-4(3H)-one Derivatives as Active Agents against Toxoplasma gondii. J Agric Food Chem. 2025 Mar 12;73(10):6215-6230.  [Content Brief]