2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs) ADC Linker
  4. TCO-GK-PEG4-NHS ester

TCO-GK-PEG4-NHS ester 是一种 ADC Linker，可用于合成[18F]AlF-NOTA-Tz-TCO-GK-2Rs15d。[18F]AlF-NOTA-Tz-TCO-GK-2Rs15d 以高亲和力和免疫反应性与 HER2 结合。TCO-GK-PEG4-NHS ester 是一种点击化学试剂。它含有 TCO 基团，可以和含有 Tetrazine 基团的分子发生逆电子需求 Diels-Alder?反应 (iEDDA)。

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TCO-GK-PEG4-NHS ester Chemical Structure

TCO-GK-PEG4-NHS ester Chemical Structure

CAS No. : 2307311-19-7

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TCO-GK-PEG4-NHS ester 相关抗体

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查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2[1]. TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target

RDC Bifunctional Chelator

 

分子量

728.78

Formula

C33H52N4O14
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TCO-GK-PEG4-NHS ester 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-GK-PEG4-NHS ester2307311-19-7Radionuclide-Drug Conjugates (RDCs)ADC LinkerAntibody-drug conjugates linkerADCsHER2linkerInhibitorinhibitorinhibit

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