2. Anti-infection
  3. Penicillin-binding protein (PBP) Bacterial Antibiotic
  4. Tebipenem pivoxil hydrochloride

Tebipenem pivoxil hydrochloride  (Synonyms: L084 hydrochloride)

目录号: HY-B0396A
产品使用指南

摩尔计算器

Tebipenem pivoxil (L084) hydrochloride 是一种抗多种致病菌的具有口服活性的抗生素。 Tebipenem pivoxil hydrochloride 结合青霉素结合蛋白 (PBP)，从而抑制细胞壁合成。

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Tebipenem pivoxil hydrochloride Chemical Structure

Tebipenem pivoxil hydrochloride Chemical Structure

CAS No. : 211558-19-9

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Tebipenem pivoxil hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Tebipenem pivoxil hydrochloride:

Tebipenem pivoxil hydrochloride 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tebipenem pivoxil (L084) hydrochloride is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil hydrochloride binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis[1].

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

Tebipenem pivoxil hydrochloride (0-128 μg/mL, 18–24 h) displays excellent antibacterial activity against a variety of pathogenic bacteria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tebipenem pivoxil hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Gram-positive and Gram-negative bacteria
Concentration: 0-128 μg/mL
Incubation Time: 18–24 h
Result: Showed inhibition with MIC50s below 64 μg/mL against tested Gram-positive and Gram-negative bacteria.
体内研究
(In Vivo)

Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) hydrochloride shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice[1].
Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) hydrochloride significantly protects the sepsis mice challenged with various pathogenic bacteria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM mice weighing 18–22 g[1]
Dosage: 2.89, 3.40 and 4.00 g/kg
Administration: Oral administration (tablet), once
Result: Within the 14-day observation period, only one mouse was dead in the maximum oral dosage (4.00 g/kg). The minimal lethal dosage (MLD) was 4.00 g/kg and the maximum tolerance dosage (MTD) in the mice was 3.40 g/kg. Showed dose-dependent liver and kidney damage.
Animal Model: ICR mice, sepsis mouse models[1]
Dosage: 50 and 100 mg/kg
Administration: Oral administration (tablet), once
Result: Significantly increased the survival number of the sepsis mice within a 168 h observation period.
Clinical Trial
分子量

534.09

Formula

C22H32ClN3O6S2
CAS 号
中文名称

泰比培南酯盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tebipenem pivoxil hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tebipenem pivoxil211558-19-9L084泰比培南酯盐酸盐L 084L-084Penicillin-binding protein (PBP)BacterialAntibioticbroad antibacterial spectrumStreptococcus pneumoniaErythromycin-resistant Streptococcus pneumoniaHaemophilus influenzaorally activepenicillin-binding proteinInhibitorinhibitorinhibit

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