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  4. Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium

Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium 

目录号: HY-139722
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摩尔计算器

Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) 在人肝微粒体中表现出比 tenofovir 更长的 t1/2 值，在体外具有有效的抗 HIV 活性，并增强体内的药代动力学特性。

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Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium Chemical Structure

Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium Chemical Structure

CAS No. : 2611373-74-9

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Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T CC50
> 100 μM
Compound: 23
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CellTiter 96 Aqueous One Solution reagent based cell proliferation assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CellTiter 96 Aqueous One Solution reagent based cell proliferation assay
[PMID: 34459598]
分子量

626.84

Formula

C29H55N6O5PSi
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tenofovir-C3-O-C12-trimethylsilylacetylene2611373-74-9HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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