2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR VEGFR Src
  4. Tesevatinib tosylate

Tesevatinib tosylate  (Synonyms: XL-647 tosylate; EXEL-7647 tosylate; KD-019(tosylate))

目录号: HY-13314A
产品使用指南 技术支持

Tesevatinib (XL-647) tosylate 是一种可口服的、能够穿透血脑屏障的表皮生长因子受体 (EGFR) 抑制剂。Tesevatinib tosylate 能显著降低细胞活力，在 GBM12 和 GBM6 的 IC50 为 11 nM 和 102 nM。Tesevatinib tosylate 还能抑制 HER2 (IC50=16.1 nM)，VEGFR2 (IC50=1.5 nM) 和 Src (IC50=10.3 nM)。Tesevatinib tosylate 可抑制肿瘤增殖，具有抗肿瘤活性。

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Tesevatinib tosylate Chemical Structure

Tesevatinib tosylate Chemical Structure

CAS No. : 1000599-06-3

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Tesevatinib tosylate 的其他形式现货产品:

Customer Review

Other Forms of Tesevatinib tosylate:

Tesevatinib tosylate 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tesevatinib (XL-647) tosylate is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib tosylate significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib tosylate also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM). Tesevatinib tosylate can inhibit tumor proliferation and exhibits antitumor activity[1][2].

IC50 & Target

HER2

16.1 nM (IC50)

VEGFR2

1.5 nM (IC50)

分子量

663.59

Formula

C31H33Cl2FN4O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tesevatinib tosylate 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tesevatinib1000599-06-3XL-647EXEL-7647KD-019(tosylate)XL647XL 647EXEL7647EXEL 7647EGFRVEGFRSrcEpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorAnti-tumorepidermal growth factorblood-brain barrieroralInhibitorinhibitorinhibit

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