1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Thrombin inhibitor 6

Thrombin inhibitor 6 是一种有效的凝血酶 (thrombin) 抑制剂 (IC50: 1 nM)。Thrombin inhibitor 6 具有抗凝作用。

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Thrombin inhibitor 6 Chemical Structure

Thrombin inhibitor 6 Chemical Structure

CAS No. : 1628224-94-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].

体外研究
(In Vitro)

Thrombin inhibitor 6 (compound 73) 在与 CD-1 小鼠和人微粒体孵育时是稳定的 (Clint (小鼠) = 60 μL/min/mg;Clint (人) = 17 μL/min/mg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Thrombin inhibitor 6 (compound 73) (9 mg/kg,静脉注射) 可延长 CD-1 小鼠的尾部出血时间[1]
Thrombin inhibitor 6 (compound 73) (5 mg/kg,口服) 在雄性 CD-1 小鼠中的 F(%) 为 22.8%,AUC 为 713.3 h.ng/mL,Cmax 为 127 ng/mL[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice[1]
Dosage: 9 mg/kg
Administration: Intravenous injection (i.v.)
Result: The mice bled for 25 min following transection.
Led to 1.5-fold increase of liberated whole blood cells.
分子量

390.89

Formula

C18H19ClN4O2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Thrombin inhibitor 6 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Thrombin inhibitor 6
目录号:
HY-151983
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