1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Tislelizumab

Tislelizumab  (Synonyms: 替雷利珠单抗)

目录号: HY-P99052 纯度: 98.10%
COA

Tislelizumab 是一种能特异性结合细胞程序性死亡受体 1 (PD-1) 的单克隆抗体,阻断其与程序性死亡配体 1 (PD-L1) 和程序性死亡配体 2 (PD-L2) 的相互作用。Tislelizumab 可使 T 淋巴细胞等免疫细胞重新激活,增强抗肿瘤的活性。Tislelizumab 被用于经典型霍奇金淋巴瘤、尿路上皮癌、非小细胞肺癌和肝细胞癌等多种肿瘤的研究。

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CAS No. : 1858168-59-8

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规格 价格 是否有货 数量
1 mg ¥1200
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5 mg ¥3500
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10 mg ¥5500
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25 mg ¥8625
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50 mg ¥11388
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100 mg ¥15360
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma[1][2][3].

同型

Human IgG4 kappa

推荐同型对照抗体
种属

Humanized

体内研究
(In Vivo)

Tislelizumab (10 mg/kg; 腹腔注射; 每周一次; 4 周) 在 B16F10 黑色素瘤小鼠模型中具有显著的抗肿瘤作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10/GM-CSF tumor cells treated hPD-1 C57BL/6 transgenic mice[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.); once a week for 4 weeks.
Result: Exerted remarkable antitumor efficacy, resulting in approximate 86.7% tumor growth inhibition.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG4 kappa
Biological Activity
  • Flow cytometry analysis of PD-1 overexpression Jurkat cells labelling PD-1 with Tislelizumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
纯度 & 产品资料

纯度: 98.10%

参考文献
  • 摩尔计算器

  • 稀释计算器

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tislelizumab
目录号:
HY-P99052
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