2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Tolafentrine

Tolafentrine 是一种双选择性磷酸二酯酶 3/4 (PDE3/4) 抑制剂，研究表明它在单侧双乙酰胺诱导的大鼠肺动脉高压模型中具有显著的急性和慢性效应。实验显示，长期给药可以显著减轻所有单侧双乙酰胺引起的血流动力学和气体交换异常，减少右心室肥大，并正常化肺血管重构变化。

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Tolafentrine Chemical Structure

Tolafentrine Chemical Structure

CAS No. : 139308-65-9

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Tolafentrine 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes[1].

分子量

505.63

Formula

C28H31N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tolafentrine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tolafentrine139308-65-9Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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