2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. ADC Cytotoxin Microtubule/Tubulin
  4. Tubulysin D

Tubulysin D  (Synonyms: 微管蛋白抑制剂 D)

目录号: HY-N2348
产品使用指南

摩尔计算器

Tubulysin D 是具有高细胞毒性的抗微管毒素 (anti-microtubule toxins)，作为 ADC 细胞毒素 (ADC Cytotoxin) 合成 ADC。Tubulysin D 能够从粘细菌 Archangium geophyra 和 Angiococcus disciformis 中分离得到。Tubulysin D 在哺乳动物细胞中显示出极其有效的细胞毒活性，包括多药耐药细胞系，IC50 值在较低的纳摩尔范围内。Tubulysin D 可抑制微管蛋白 (Microtubule/Tubulin) 聚合并导致细胞周期停滞和凋亡 (apoptosis)。

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Tubulysin D Chemical Structure

Tubulysin D Chemical Structure

CAS No. : 309935-57-7

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Tubulysin D 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

IC50 & Target

IC50: 1.7 μM (Tubulin)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.013 nM
Compound: 1b
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 21106374]
HCT-116 IC50
0.0031 nM
Compound: 1b
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 21106374]
HL-60 IC50
0.0047 nM
Compound: 1b
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 21106374]
MCF7 IC50
0.67 nM
Compound: 1b
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 21106374]
体外研究
(In Vitro)

Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulysin D 相关抗体:
分子量

828.07

Formula

C43H65N5O9S
CAS 号
中文名称

微管蛋白抑制剂 D
结构分类
初始来源

Archangium geophyra、Angiococcus disciformis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulysin D 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulysin D309935-57-7微管蛋白抑制剂 DADC CytotoxinMicrotubule/TubulinADC PayloadInhibitorinhibitorinhibit

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