2. Immunology/Inflammation
  3. Interleukin Related
  4. Tucotuzumab

Tucotuzumab  (Synonyms: 西莫白介素单抗; Anti-EPCAM Recombinant Antibody; huKS-IL2)

目录号: HY-P99328 纯度: ≥95.0%
COA

摩尔计算器

Tucotuzumab (Anti-EPCAM Recombinant Antibody) 一种由靶向人上皮细胞粘附分子 (EpCAM) 的抗原特异性 IgG1 单克隆抗体。Tucotuzumab 可连接两个 IL-2 分子，是一种免疫抑制剂和抗肿瘤活性分子。

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Tucotuzumab Chemical Structure

Tucotuzumab Chemical Structure

CAS No. : 339986-90-2

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规格 价格 是否有货 数量
1 mg ￥2600
In-stock
5 mg ￥6800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Tucotuzumab 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule[1].

种属

Humanized

体外研究
(In Vitro)

Tucotuzumab 靶向肿瘤并通过 IL-2 应答性免疫细胞刺激抗肿瘤免疫反应，以及通过其 Fc 受体刺激免疫细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tucotuzumab 相关抗体:
体内研究
(In Vivo)

Tucotuzumab (75 μg; 瘤内注射; 每日 5 次，每次15 μg (总剂量 75 μg)，各用50 μL PBS; 在第 10 天和第 14 天)，肿瘤生长抑制显著增强，生存率提高[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice bearing CT26-KS colon adenocarcinoma[1]
Dosage: 75 μg
Administration: Intratumoral injection; 5 daily of 15 μg (total dose of 75 μg), each in 50 μL PBS; on days 10 and 14
Result: Resulted in significantly greater tumor growth suppression and enhanced survival.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

西莫白介素单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Tucotuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tucotuzumab339986-90-2Anti-EPCAM Recombinant Antibody huKS-IL2西莫白介素单抗Interleukin RelatedILEPCAMIgG1 monoclonal antibodyIL-2immunosuppressant and antineoplastic agentInhibitorinhibitorinhibit

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