2. Others
  3. Isotope-Labeled Compounds
  4. Ursodeoxycholic acid-2,2,4,4-d4

Ursodeoxycholic acid-2,2,4,4-d4  (Synonyms: 熊去氧胆酸 d4)

目录号: HY-113478S 纯度: 99.52%
COA 产品使用指南

摩尔计算器

Ursodeoxycholic acid-2,2,4,4-d4 是 Ursodeoxycholic acid (HY-13771) 的氘代物。Ursodeoxycholic acid 是由肠道细菌转化 (cheno) 脱氧胆酸而产生的一种次级胆汁酸，是肠道屏障完整性的关键调节因子，对脂质代谢至关重要。Ursodeoxycholic acid 作为信号分子，通过与胆汁酸激活的受体相互作用发挥作用，包括 G 蛋白偶联的胆汁酸受体 5 (TGR5, GPCR19) 和法尼酯 X 受体 (FXR)。Ursodeoxycholic acid 可用于多种肝脏和胃肠道疾病的研究。Ursodeoxycholic acid 也减少 ACE2 的表达，有助于减少 SARS-CoV-2 感染。

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Ursodeoxycholic acid-2,2,4,4-d<sub>4</sub> Chemical Structure

Ursodeoxycholic acid-2,2,4,4-d4 Chemical Structure

CAS No. : 347841-46-7

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规格 价格 是否有货 数量
500 μg ￥600
In-stock
1 mg ￥1100
In-stock
5 mg ￥3850
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of Ursodeoxycholic acid-2,2,4,4-d4:

Ursodeoxycholic acid-2,2,4,4-d4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ursodeoxycholic acid-2,2,4,4-d4 is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection[1][2][3][4][5].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ursodeoxycholic acid-2,2,4,4-d4 相关抗体:
分子量

396.60

Formula

C24H36D4O4
CAS 号
非标记 CAS
性状

固体

颜色

White to off-white

中文名称

熊去氧胆酸 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMF 中的溶解度 : ≥ 10 mg/mL (25.21 mM)

DMSO 中的溶解度 : ≥ 10 mg/mL (25.21 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Ethanol 中的溶解度 : ≥ 1 mg/mL (2.52 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5214 mL 12.6072 mL 25.2143 mL
5 mM 0.5043 mL 2.5214 mL 5.0429 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.52%

COA (290 KB) HNMR (317 KB) RP-HPLC (344 KB)

产品使用指南 (1538 KB)
参考文献

Ursodeoxycholic acid-2,2,4,4-d4 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF / DMSO 1 mM 2.5214 mL 12.6072 mL 25.2143 mL 63.0358 mL
DMF / DMSO 5 mM 0.5043 mL 2.5214 mL 5.0429 mL 12.6072 mL
10 mM 0.2521 mL 1.2607 mL 2.5214 mL 6.3036 mL
15 mM 0.1681 mL 0.8405 mL 1.6810 mL 4.2024 mL
20 mM 0.1261 mL 0.6304 mL 1.2607 mL 3.1518 mL
25 mM 0.1009 mL 0.5043 mL 1.0086 mL 2.5214 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ursodeoxycholic acid-2,2,4,4-d4347841-46-7熊去氧胆酸 d4Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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