2. Stem Cell/Wnt Epigenetics Cell Cycle/DNA Damage Autophagy Anti-infection Neuronal Signaling Apoptosis Metabolic Enzyme/Protease
  3. Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
  4. Valproic acid (sodium)

Valproic acid (sodium)  (Synonyms: Sodium Valproate (sodium))

目录号: HY-10585AG
产品使用指南 技术支持

Valproic acid sodium (Sodium Valproate) (GMP) 是 GMP 级别的Valproic acid sodium (HY-10585A)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Valproic acid (Sodium Valproate) sodium 是一种具有口服活性的 HDAC 抑制剂，IC50 值为 0.5-2 mM，抑制 HDAC1 的活性，(IC50，400 μM)，同时可诱导 HDAC2 的降解。Valproic acid sodium 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid sodium 可用于癫痫、双相情感障碍、代谢疾病、HIV 感染和偏头痛等的研究。

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Valproic acid (sodium) Chemical Structure

Valproic acid (sodium) Chemical Structure

CAS No. : 1069-66-5

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Valproic acid (sodium) 的其他形式现货产品:

Other Forms of Valproic acid (sodium):

Valproic acid (sodium) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7].

IC50 & Target

IC50: 400 μM (HDAC1), 0.5-2 mM (HDAC)[5] HDAC2[6]
体外研究
(In Vitro)

Valproic acid (VPA) (0-15 mM；24 和 72 小时) 以剂量和时间依赖性方式抑制 Hela 细胞生长[1]。
Valproic acid (10 mM；24 小时) 显著减弱总、胞质溶胶和核 HDAC 的活性[1]。
Valproic acid (0-15 mM；24 小时) 在 1-3 mM 时诱导 G1 期停滞，在 10 mM 时诱导 G2/M 期停滞，并增加 HeLa 细胞中亚 G1 细胞的百分比。Valproic acid还会诱导坏死、凋亡和乳酸脱氢酶 (LDH) 释放[1]。
Valproic acid (0-20 mM；24 小时) 激活 Tcf/Lef 依赖性转录并与锂产生协同作用[2]。
Valproic acid (0-5 mM；0-18 小时) 增加 Neuro2A 细胞中的 β-catenin 水平[2]。
Valproic acid (0-2 mM；0-24 小时) 刺激肝细胞中 AMPK 和 ACC 的磷酸化[5]。
Valproic acid (0-10 mM；2 天) 诱导 Notch1 信号传导和形态分化，抑制 SCLC 中 NE 肿瘤标志物的产生细胞[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Valproic acid (sodium) 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 0, 1, 3, 5, 10 and 15 mM
Incubation Time: 24 and 72 h
Result: HeLa cell growth was dose- and time-dependently decreased with an IC50 of ~10 and 4 mM at 24 and 72 h.

Western Blot Analysis[1][2][5]

Cell Line: HeLa cells, Neuro2A cells or primary mouse hepatocytes
Concentration: 10 mM (HeLa); 0, 2, and 5 mM (Neuro2A); 0.2, 0.4, 0.8, 1.2 and 2 mM (hepatocytes)
Incubation Time: 24 h (HeLa); 0-18 h (Neuro2A); 0-24 h (hepatocytes)
Result: Increased the form of acetylated histone 3.
Reduced PARP, induced cleavage PARP, and downregulated Bcl-2.
Increased β-catenin levels.
Increased the phosphorylation of AMPK and ACC.

Cell Cycle Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 1, 3, 5, 10 and 15 mM
Incubation Time: 24 h
Result: Induced a G1 phase arrest at 1–3 mM, significantly induced a G2/M phase arrest at 10 mM, and increased the percentage of sub-G1 cells in HeLa cells in a dose-dependent manner at 24 h.
体内研究
(In Vivo)

Valproic acid (VPA) (500 mg/kg；腹腔注射；每日一次连续 12 天) 可抑制移植了 Kasumi-1 细胞的小鼠的肿瘤血管生成[3]。
Valproic acid (350 mg/kg；腹腔注射；单剂量) 可增强大鼠的社交行为[4]。
Valproic acid (0.26% (w/v)；通过饮用水口服；14 天) 可降低肥胖小鼠的肝脏质量、肝脏脂肪堆积和血糖，且无肝毒性[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice, Kasumi-1 tumor model[3]
Dosage: 500 mg/kg
Administration: Intraperitoneal injection, daily for 12 days
Result: Inhibited tumor growth and tumor angiogenesis.
Inhibited the mRNA and protein expression of VEGF, VEGFR2 and bFGF.
Inhibited HDAC activity and increased acetylation of histone H3.
Enhanced the accumulation of hyperacetylated histone H3 on VEGF promoters.
Animal Model: Timed-pregnant Long Evans rats[4]
Dosage: 350 mg/kg
Administration: Intraperitoneal injection, once
Result: Demonstrated more social investigation and play fighting than control animals.
Animal Model: Obese phenotype of ob/ob mice[5]
Dosage: 0.26% (w/v)
Administration: Oral via drinking water, 14 days
Result: Revealed a marked reduction in the accumulation of fats in the liver as compared with the untreated mice, significantly decreased liver mass to body mass, decreased serum triglyceride concentrations, and did not induce hepatotoxicity.
分子量

166.19

Formula

C8H15NaO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Valproic acid (sodium) 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valproic acid (sodium) (GMP)1069-66-5Sodium Valproate sodium (GMP)OrganoidHDACAutophagyMitophagyHIVNotchApoptosisEndogenous MetaboliteHistone deacetylasesMitochondrial AutophagyHuman immunodeficiency virusHelaproteasomaldegradationNotch1SCLCepilepsybipolar disordermigraineheadachessmall cell lung canceranticanceranticonvulsanthepatic fat accumulationInhibitorinhibitorinhibit

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