2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CCR HIV
  4. Vicriviroc malate

Vicriviroc malate  (Synonyms: SCH 417690 malate; SCH-D malate; MK-7690)

目录号: HY-B0155B
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摩尔计算器

Vicriviroc (SCH 417690) malate 是一种具有口服活性的 CCR5 拮抗剂，其 IC50 > 值为 10 nM，还能抑制 MIP-1α 和 RANTES 配体诱导的细胞内钙释放，其 IC50 值分别为 0.91 nM 和 16 nM。Vicriviroc malate 可抑制人类免疫缺陷病毒 1 型 (HIV-1) 感染，也可以用于癌症的研究。

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Vicriviroc malate Chemical Structure

Vicriviroc malate Chemical Structure

CAS No. : 541503-81-5

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Vicriviroc malate 的其他形式现货产品:

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Vicriviroc malate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vicriviroc (SCH 417690) malate is an orally active CCR5 antagonist with the IC50 of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC50 values of 0.91 nM and 16 nM,,respectively. Vicriviroc malate can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer[1][2].

分子量

667.72

Formula

C32H44F3N5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vicriviroc malate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vicriviroc541503-81-5SCH 417690SCH-D MK-7690SCH417690SCH-417690MK7690MK 7690MK-7690CCRHIVCC chemokine receptorHuman immunodeficiency virusBa/F3-CCR5 cellsColorectal CancerHIV-1Inhibitorinhibitorinhibit

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