2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Endogenous Metabolite Cannabinoid Receptor
  4. Virodhamine

Virodhamine 是一种内源性大麻素，它通过激活大麻素 (CB) 受体调节神经传递。Virodhamine 是 CB1 受体的拮抗剂和 CB2 受体的激动剂。Virodhamine 通过触发 MAPK 信号和 ROS 的产生诱导巨核细胞分化。 Virodhamine 可用于治疗各种神经疾病，如阿尔茨海默病和帕金森。

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Virodhamine Chemical Structure

Virodhamine Chemical Structure

CAS No. : 287937-12-6

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规格 价格 是否有货 数量
5 mg ￥850
In-stock
10 mg ￥1450
In-stock
25 mg ￥3000
In-stock
50 mg ￥4850
In-stock
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500 mg   询价  

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Customer Review

Other Forms of Virodhamine:

Virodhamine 相关抗体

Top Publications Citing Use of Products

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases[1][2].

体外研究
(In Vitro)

Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus[1].
Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1[1].
Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control[1].
Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Virodhamine 相关抗体:

RT-PCR[1]

Cell Line: Megakaryocyte cell line
Concentration: 10, 20 and 40 μM
Incubation Time: 72 h
Result: Dose‐dependently enhanced the expression level of megakaryocytic marker CD61 and the expression of TRPV1 mRNA.
体内研究
(In Vivo)

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety[2]
Dosage: 1, 5 and 10 mg/kg
Administration: Intraperitoneal injection; 1-10 mg/kg; once
Result: Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.
分子量

347.53

Formula

C22H37NO2
CAS 号
性状

粘稠液体

颜色

Yellow to brown

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (287.74 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8774 mL 14.3872 mL 28.7745 mL
5 mM 0.5755 mL 2.8774 mL 5.7549 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Virodhamine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8774 mL 14.3872 mL 28.7745 mL 71.9362 mL
5 mM 0.5755 mL 2.8774 mL 5.7549 mL 14.3872 mL
10 mM 0.2877 mL 1.4387 mL 2.8774 mL 7.1936 mL
15 mM 0.1918 mL 0.9591 mL 1.9183 mL 4.7957 mL
20 mM 0.1439 mL 0.7194 mL 1.4387 mL 3.5968 mL
25 mM 0.1151 mL 0.5755 mL 1.1510 mL 2.8774 mL
30 mM 0.0959 mL 0.4796 mL 0.9591 mL 2.3979 mL
40 mM 0.0719 mL 0.3597 mL 0.7194 mL 1.7984 mL
50 mM 0.0575 mL 0.2877 mL 0.5755 mL 1.4387 mL
60 mM 0.0480 mL 0.2398 mL 0.4796 mL 1.1989 mL
80 mM 0.0360 mL 0.1798 mL 0.3597 mL 0.8992 mL
100 mM 0.0288 mL 0.1439 mL 0.2877 mL 0.7194 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Virodhamine287937-12-6Endogenous MetaboliteCannabinoid ReceptorendocannabinoiMAPKROSmegakaryocytic differentiationneurological disorderAlzheimer's disease Parkinson's diseaseInhibitorinhibitorinhibit

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