2. Anti-infection Apoptosis
  3. Bacterial Apoptosis
  4. Vitexilactone

Vitexilactone 是一种二萜类化合物，可从黄荆 (Vitex negundo L.) 的叶片中分离出来。Vitexilactone 对 E. coli 具有抑菌活性。Vitexilactone 诱导癌细胞凋亡并抑制细胞周期。Vitexilactone 可用于癌症的研究。

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Vitexilactone Chemical Structure

Vitexilactone Chemical Structure

CAS No. : 61263-49-8

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规格 价格 是否有货 数量
1 mg ￥3000
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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Customer Review

Vitexilactone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 23327905]
HCT-116 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 23327905]
HCT-116 GI50
> 5000 ng/mL
Compound: 13
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
HL-60 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23327905]
PC-12 GI50
> 5000 ng/mL
Compound: 13
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
RAW264.7 IC50
42.5 μM
Compound: 1
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 24035341]
ZR-75-30 IC50
< 5 μg/mL
Compound: Vitexilactone
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
[PMID: 23327905]
体外研究
(In Vitro)

Vitexilactone 对 E. coli 表现出显著的抗菌活性，MIC 值 >90 μg/mL[1]。
Vitexilactone (0-100 μg/mL; 17-24 h) 抑制哺乳动物癌细胞的增殖[2]。
Vitexilactone (25-100 μg/mL; 17 h) 高浓度时诱导细胞凋亡，低浓度时抑制细胞周期 G0/G1期，在 tsFT210 和 K562 细胞中[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vitexilactone 相关抗体:

Cell Proliferation Assay[2]

Cell Line: tsFT210 and K562 cells lines
Concentration: 0-100 μg/mL
Incubation Time: 17-24 hours
Result: Inhibited cell proliferation of mammalian cancer cells with IC50 values of 86.9 and 57.9 μg/mL for tsFT210 and K562 cells, respectively.

Apoptosis Analysis[2]

Cell Line: tsFT210 and K562 cell lines
Concentration: 25-100 μg/mL
Incubation Time: 17 hours
Result: Induced cell apoptosis of tsFT210 with a MIC value of 25 μg/mL.

Cell Cycle Analysis[2]

Cell Line: tsFT210 and K562 cell lines
Concentration: 25-100 μg/mL
Incubation Time: 17 hours
Result: Inhibited G0/G1 phase of cell cycle with the dose ranges of 50-6.25 μg/mL in tsFT210 cells.
分子量

378.50

Formula

C22H34O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vitexilactone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vitexilactone61263-49-8BacterialApoptosisditerpenoidnatural productantimicrobialapoptosiscell cyclecancertsFT210K562Inhibitorinhibitorinhibit

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