2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Vorozole

Vorozole  (Synonyms: (+)-Vorozole; R83842)

目录号: HY-19599
产品使用指南

摩尔计算器

Vorozole 是一种有效的，选择性的，具有口服活性的非甾体 芳香酶 抑制剂。Vorozole 表现出体内抗肿瘤作用。Vorozole 具有研究乳腺癌的潜力。

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Vorozole Chemical Structure

Vorozole Chemical Structure

CAS No. : 129731-10-8

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规格 价格 是否有货 数量
1 mg ￥2278
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of Vorozole:

Vorozole 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3].

IC50 & Target

Aromatase

 

体外研究
(In Vitro)

Vorozole inhibits aromatase activity with an IC50s of 1.4 nM in FSH-stimulated rat granulosa cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vorozole 相关抗体:
体内研究
(In Vivo)

Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 dayss) shows antitumor effect and increase the release of serum insulin-like growth factor (IGF)-1 and serum testosterone levels[3].
Vorozole (p.o.; 5 days) dose-dependently reduced uterus weight and completely inhibited tumor aromatase in ovariectomized nude mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats[3]
Dosage: 0.08, 0.16, 0.31, 0.63 or 1.25 mg/kg
Administration: Gavage; daily (starting at 43 days of age) for 77 days; given a single i.v. dose of methylnitrosourea (MNU) (50 mg/kg body wt) after 7 days
Result: Caused a dose-dependent increase in body weight gain and decrease in cancer incidence, increased the insulin-like growth factor (IGF)-1, serum testosterone levels.
分子量

324.77

Formula

C16H13ClN6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vorozole 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vorozole129731-10-8(+)-Vorozole R83842R83842R 83842R-83842Cytochrome P450CYPstriazole derivativeselectiveorally activeantitumormammary cancertestosteroneinsulin-like growth factor (IGF)-1Inhibitorinhibitorinhibit

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