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VPC12249 是一种竞争性的双重 LPA1/LPA3 拮抗剂,Ki 值分别为 137 nM 和 428 nM。VPC12249 在 HEK293T 细胞中抑制钙的动员,Ki 值约为 130 nM。VPC12249 有望用于卵巢癌和高血压疾病的研究。

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VPC12249 Chemical Structure

VPC12249 Chemical Structure

CAS No. : 403520-23-0

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生物活性

VPC12249 is a competitive dual LPA1/LPA3 antagonist with Ki values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a Ki value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases[1].

分子量

601.75

Formula

C34H52NO6P

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
VPC12249
目录号:
HY-129808
需求量: