1. Metabolic Enzyme/Protease Immunology/Inflammation
  2. Indoleamine 2,3-Dioxygenase (IDO) NO Synthase
  3. VS-15

VS-15是一种 IDO1 抑制剂,选择性地与无血红素形式的 IDO1 结合。VS-15 也是一种 iNOS 抑制剂。

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VS-15 Chemical Structure

VS-15 Chemical Structure

CAS No. : 951948-78-0

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查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看 NO Synthase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VS-15, a IDO1 inhibitor, selectively binds the heme-free form of IDO1. VS-15 is described as an iNOS inhibitor based on the reduction of NO production[1].

体外研究
(In Vitro)

VS-15 通过负面干扰 IDO1 与 SHPs 和 PI3K 调节亚单位 p85 的合作关系,以及 IDO1 在肿瘤细胞早期内体的锚定,来减少 IDO1 介导的信号通路[1]
VS-15 抵消了 TGF-β 介导的树突状细胞的免疫抑制表型,并减少了由胰腺癌患者分离的抑制性单核细胞对 T 细胞增殖的抑制水平[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

493.56

Formula

C29H27N5O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
VS-15
目录号:
HY-168092
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