2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0410425

VU0410425 是一种 mGlu1 负变构调节剂。 VU0410425 对大鼠 mGlu1 表现出有效的抑制活性，IC50 值为 140 nM。 VU0410425 可用于中枢神经系统疾病的研究.

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VU0410425 Chemical Structure

VU0410425 Chemical Structure

CAS No. : 1341167-72-3

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VU0410425 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU0410425 is an mGlu1 negative allosteric modulator. VU0410425 exhibits potent inhibitory activity for rat mGlu1 with an IC50 value of 140 nM. VU0410425 can be used for the research of central nervous system disorders[1].
IC50 & Target

IC50: 140 nM (rat mGlu1)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
140 nM
Compound: 7; VU0410425
Negative allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
Negative allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
[PMID: 26426481]
体外研究
(In Vitro)

VU0410425 对大鼠 mGlu1 表现出有效的抑制活性，IC50 值为 140 nM，但对人 mGlu1 无活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VU0410425 相关抗体:
分子量

369.80

Formula

C19H16ClN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU0410425 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU04104251341167-72-3VU 0410425VU-0410425mGluRMetabotropic glutamate receptorsglutamatenegative allosteric modulatormGlu1central nervous system disorders.Inhibitorinhibitorinhibit

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产品名称：
VU0410425
目录号：
HY-120428
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