2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. VU6004256

VU6004256 是一种有效的选择性 M1 毒蕈碱 (M1 muscarinic) 正变构调节剂 (PAM)，EC50 值为 155 nM。VU6004256 具有精神分裂症研究的潜力。

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VU6004256 Chemical Structure

VU6004256 Chemical Structure

CAS No. : 2011034-33-4

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VU6004256 相关抗体

Top Publications Citing Use of Products

查看 mAChR 亚型特异性产品:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia[1].

IC50 & Target[1]

mAChR1

155 nM (EC50)

体内研究
(In Vivo)

VU6004256 (10 mg/kg; i.p.) 减弱 NR1 KD 小鼠前额皮质中过度的锥体细胞放电[1]。
VU6004256 (3, 10 mg/kg; i.p.) 逆转 NR1 KD 小鼠新物体识别和提示介导的恐惧条件反射任务中的表现障碍并减少过度运动活动[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male NR1 KD mice[1]
Dosage: 10 mg/kg
Administration: I.p.
Result: Showed no effect on pyramidal cell firing rate in WT littermate controls, significantly reduced pyramidal cell firing rate in NR1 KD mice.
Animal Model: Wild-type and NR1 KD mice[1]
Dosage: 3, 10 mg/kg
Administration: I.p.
Result: Dose-dependently reduced locomotor activity in NR1 KD, but not in WT mice, resulted in dose-dependent increases in recognition index in WT and NR1 KD mice; improved performance on test day in cue-mediated conditioned freezing in NR1 KD but not WT mice.
分子量

465.50

Formula

C25H25F2N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU6004256 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60042562011034-33-4VU 6004256VU-6004256mAChRMuscarinic acetylcholine receptorschizophreniaNR1 KD micenovel object recognitioncue-mediated fearhyper locomotor activityInhibitorinhibitorinhibit

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产品名称：
VU6004256
目录号：
HY-117408
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