1. GPCR/G Protein Neuronal Signaling
  2. mAChR
  3. VU6036864

VU6036864 (compound 45) 是一种口服有效、选择性的 mAChR M5 的拮抗剂,对人类 M5 的 IC50=20 nM。VU6036864 对人类 M1-4 的选择性 >500 倍,脑暴露和高口服生物利用度 (%F>100%)。

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VU6036864 Chemical Structure

VU6036864 Chemical Structure

CAS No. : 2746406-36-8

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查看 mAChR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU6036864 (compound 45) is an orally active, selective mAChR M5 antagonist with IC50=20 nM for human M5. VU6036864 is >500-fold selective for human M1-4, with BBB characteristic and high oral bioavailability (%F>100%)[1].

IC50 & Target

IC50: 20 nM (human mAChR M5)[1]

分子量

385.86

Formula

C15H12D4ClN5O3S

CAS 号
非标记 CAS

2746405-41-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
VU6036864
目录号:
HY-159578S
需求量: