2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Xylometazoline

Xylometazoline  (Synonyms: 赛洛唑啉)

目录号: HY-B0475A
产品使用指南 技术支持

Xylometazoline 是一种 α-肾上腺素能受体激动剂 (Ki=0.05-1.7 μM)。Xylometazoline 可收缩鼻腔血管，增加鼻腔气流。Xylometazoline 可用于鼻塞和流鼻涕的研究。

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Xylometazoline Chemical Structure

Xylometazoline Chemical Structure

CAS No. : 526-36-3

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Xylometazoline 的其他形式现货产品:

Other Forms of Xylometazoline:

Xylometazoline 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2][3][4].

IC50 & Target[2]

Alpha-1A adrenergic receptor

0.05 μM (Ki)

Alpha-1B adrenergic receptor

0.30 μM (Ki)

Alpha-1D adrenergic receptor

0.15 μM (Ki)

Alpha-2A adrenergic receptor

0.88 μM (Ki)

Alpha-2B adrenergic receptor

1.7 μM (Ki)

Alpha-2C adrenergic receptor

0.19 μM (Ki)

体外研究
(In Vitro)

Xylometazoline 在 HEK293 细胞中对 α1A-肾上腺素受体和 α2B-肾上腺素受体具有亲和力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xylometazoline 相关抗体:
体内研究
(In Vivo)

Xylometazoline (1 mg/mL，鼻内给药，单次剂量) 可改善大鼠的鼻窦炎[3]。
Xylometazoline 及其辅料的长期使用可能导致眼部问题，如干眼症、角膜水肿、白内障、视网膜神经纤维层损伤和血管损害[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SpragueDawley rat induced by platelet-activating factor[3]
Dosage: 1 mg/mL; single dose
Administration: Intranasal administration
Result: Showed almost no vascular congestion, little infiltration, and the epithelium was completely intact.
分子量

244.38

Formula

C16H24N2
CAS 号
中文名称

赛洛唑啉
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Xylometazoline 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xylometazoline526-36-3赛洛唑啉Adrenergic ReceptorBeta Receptorconstrict nasal blood vesselsincrease nasal airflownose stuffinessrunny noseInhibitorinhibitorinhibit

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