2. Autophagy MAPK/ERK Pathway
  3. Atg8/LC3 Raf
  4. (Z)-GW 5074

(Z)-GW 5074 是一种化合物，可以与突变型亨廷顿蛋白 (mHTT) 和 LC3 相互作用，但对野生型 HTT 无作用。(Z)-GW 5074 可抑制 c-Raf 的活性，不影响自噬，在神经退行性疾病中有效。

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(Z)-GW 5074 Chemical Structure

(Z)-GW 5074 Chemical Structure

CAS No. : 1233748-60-1

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(Z)-GW 5074 相关抗体

Top Publications Citing Use of Products

查看 Raf 亚型特异性产品:

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BRaf c-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].

IC50 & Target[1]

c-Raf

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
2.5 μM
Compound: 2; GW305074X
Inhibition of recombinant His6-tagged Kif15 ATPase activity (N420 residues) (unknown origin) expressed in HeLa cells using microtubule as substrate preincubated for 15 mins followed by ATP addition and measured after 20 mins by ADP-Glo luminescence assay
Inhibition of recombinant His6-tagged Kif15 ATPase activity (N420 residues) (unknown origin) expressed in HeLa cells using microtubule as substrate preincubated for 15 mins followed by ATP addition and measured after 20 mins by ADP-Glo luminescence assay
[PMID: 30528696]
分子量

520.94

Formula

C15H8Br2INO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Z)-GW 5074 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-GW 50741233748-60-1Atg8/LC3RafAutophagy-related 8Raf kinasesInhibitorinhibitorinhibit

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