2. NF-κB Anti-infection Metabolic Enzyme/Protease Apoptosis
  3. NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
  4. α-Lipoic Acid sodium

α-Lipoic Acid sodium  (Synonyms: Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium)

目录号: HY-N0492A 纯度: 99.92%
COA 产品使用指南

摩尔计算器

α-Lipoic Acid (Thioctic acid) sodium 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium 可抑制 NF-κB 依赖性的 HIV-1 LTR 活化。α-Lipoic Acid sodium 诱导内质网应激 (ERS) 介导的肝癌细胞凋亡 (apoptosis)。α-Lipoic Acid sodium 可与 CPUL1 (HY-151802) 合成自组装的纳米聚合体 CPUL1-LA NA，其抗肿瘤效果优于 CPUL1。

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α-Lipoic Acid sodium Chemical Structure

α-Lipoic Acid sodium Chemical Structure

CAS No. : 2319-84-8

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规格 价格 是否有货 数量
100 mg ￥200
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250 mg ￥320
In-stock
500 mg   询价  
1 g   询价  

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Customer Review

Other Forms of α-Lipoic Acid sodium:

α-Lipoic Acid sodium 相关抗体

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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HIV HIV-1 HIV-2

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1[5].

IC50 & Target

HIV-1

 

NF-κB

 

Human Endogenous Metabolite

 

Microbial Metabolite

 

体外研究
(In Vitro)

The long terminal repeat (LTR) of HIV-1 is the target of cellular transcription factors such as NF-κB, and serves as the promoter-enhancer for the viral genome when integrated in host DNA[1]. α-Lipoic Acid (Alpha-Lipoic acid, ALA), a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics. α-Lipoic Acid reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway. Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD+/NADH ratio in HepG2 cells (P<0.05 or P<0.01). Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells. α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Lipoic Acid sodium 相关抗体:
体内研究
(In Vivo)

C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid. Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed. Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice. In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

228.31

Formula

C8H13NaO2S2
CAS 号
性状

固体

颜色

White to off-white

中文名称

α-硫辛酸钠盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

H2O 中的溶解度 : 35 mg/mL (153.30 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3800 mL 21.9000 mL 43.8001 mL
5 mM 0.8760 mL 4.3800 mL 8.7600 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

α-Lipoic Acid sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.3800 mL 21.9000 mL 43.8001 mL 109.5002 mL
5 mM 0.8760 mL 4.3800 mL 8.7600 mL 21.9000 mL
10 mM 0.4380 mL 2.1900 mL 4.3800 mL 10.9500 mL
15 mM 0.2920 mL 1.4600 mL 2.9200 mL 7.3000 mL
20 mM 0.2190 mL 1.0950 mL 2.1900 mL 5.4750 mL
25 mM 0.1752 mL 0.8760 mL 1.7520 mL 4.3800 mL
30 mM 0.1460 mL 0.7300 mL 1.4600 mL 3.6500 mL
40 mM 0.1095 mL 0.5475 mL 1.0950 mL 2.7375 mL
50 mM 0.0876 mL 0.4380 mL 0.8760 mL 2.1900 mL
60 mM 0.0730 mL 0.3650 mL 0.7300 mL 1.8250 mL
80 mM 0.0548 mL 0.2738 mL 0.5475 mL 1.3688 mL
100 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0950 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Lipoic Acid2319-84-8Thioctic acid(±)-α-Lipoic acidDL-α-Lipoic acidα-硫辛酸钠盐NF-κBHIVMitochondrial MetabolismEndogenous MetaboliteApoptosisNuclear factor-κBNuclear factor-kappaBHuman immunodeficiency virusantioxidantcofactormitochondrialHIV-1LTRendoplasmicreticulumstressapoptosishepatomaInhibitorinhibitorinhibit

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