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  4. (E)-Alprenoxime

(E)-Alprenoxime  (Synonyms: CDDD-1815)

目录号: HY-101804
产品使用指南

摩尔计算器

(E)-Alprenoxime 是 Alprenoxime 的异构体。Alprenoxime 是一种位点活化的 β 阻断剂。

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(E)-Alprenoxime Chemical Structure

(E)-Alprenoxime Chemical Structure

CAS No. : 125720-84-5

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(E)-Alprenoxime 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker.

IC50 & Target

β blocker[1]
体内研究
(In Vivo)

The purpose of the present study is to explore the pharmacological significance of Alprenoxime peripheral /βblocking activity in a non-rodent animal model. Interspecies scaling considerations predict that the doses selected in this study (1 and 5 mg/kg) are pharmacologically comparable or greater than doses used in rodent studies (2 and 6 mg/kg). More importantly, the prolonged ocular antihypertensive effects that are shown with 1% ophthalmic solutions indicate that the i.v. dose tested in the present study is likely to be more than two orders of magnitude greater than probable therapeutic doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

262.35

Formula

C15H22N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Dogs[1]
Seven adult mongrel dogs (20-27 kg) are used in this study. A loading dose of Alprenoxime is administered (1 mg/kg, i.v.) followed by Alprenoxime infusion (150 μg/kg/min) after recording baseline electrophysiological parameters. Cardiac electrophysiological testing is then repeated 10 min after beginning Alprenoxime infusion. Alprenoxime (1 or 5 mg/kg, i.v.) is injected as a bolus injection and cardiac electrophysiological response is monitored. Different dogs with isoproterenol induced tachycardia are evaluated at each Alprenoxime dose.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

(E)-Alprenoxime 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

(E)-Alprenoxime125720-84-5CDDD-1815CDDD1815CDDD 1815OthersInhibitorinhibitorinhibit

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