2-Phenylethyl isothiocyanate (Synonyms: 2-PE ITC)

目录号: HY-23155 纯度: 98.04%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

2-Phenylethyl isothiocyanate 是一种有效的抗真菌剂 (antifungal)。2-Phenylethyl isothiocyanate 能显著抑制互隔交链孢霉的孢子萌发和菌丝生长，其 MIC (最低抑制浓度)为 1.22 mM。2-Phenylethyl isothiocyanate 对互隔交链孢霉的抗真菌作用可能是通过降低毒素含量和破坏细胞膜完整性来实现的。

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2-Phenylethyl isothiocyanate Chemical Structure

CAS No. : 2257-09-2

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥231	In-stock
100 mg	￥210	In-stock
500 mg	￥350	In-stock
1 g		询价
5 g		询价

or 大包装询价

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Customer Review

Other Forms of 2-Phenylethyl isothiocyanate:

2-Phenylethyl isothiocyanate-d₅ In-stock

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生物活性
纯度 & 产品资料
参考文献

生物活性

2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	16.8 μM Compound: B	Antiproliferative activity against human A549 cells after 72 hrs by SRB assay Antiproliferative activity against human A549 cells after 72 hrs by SRB assay	[PMID: 21704523]
Caco-2	IC₅₀	14 μM Compound: 1b, PEITC	Cytotoxicity against human Caco-2 cells after 72 hrs by MTS assay Cytotoxicity against human Caco-2 cells after 72 hrs by MTS assay	[PMID: 19053750]
HT-1080	IC₅₀	15 μM Compound: 1b, PEITC	Cytotoxicity against human HT1080 cells after 72 hrs by MTS assay Cytotoxicity against human HT1080 cells after 72 hrs by MTS assay	[PMID: 19053750]
LoVo	IC₅₀	13.5 μM Compound: 27	Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 26639764]
LoVo	IC₅₀	13.5 μM Compound: B	Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay Antiproliferative activity against human LoVo cells after 72 hrs by SRB assay	[PMID: 21704523]
LoVo	IC₅₀	9.8 μM Compound: B	Antiproliferative activity against doxorubicin-resistant human LoVo cells after 72 hrs by SRB assay Antiproliferative activity against doxorubicin-resistant human LoVo cells after 72 hrs by SRB assay	[PMID: 21704523]
MCF7	IC₅₀	16.3 μM Compound: B	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 21704523]
MCF7	IC₅₀	7.5 μM Compound: 1	Inhibition of Serine/threonine-protein kinase mTOR complex 1-mediated HIF1alpha RNA translation in human MCF7 cells pretreated for 1 hr prior to metabolic labeling by SDS-PAGE analysis Inhibition of Serine/threonine-protein kinase mTOR complex 1-mediated HIF1alpha RNA translation in human MCF7 cells pretreated for 1 hr prior to metabolic labeling by SDS-PAGE analysis	[PMID: 22607231]
MDA-MB-231	IC₅₀	38 μM Compound: 1b, PEITC	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTS assay	[PMID: 19053750]
MEF	IC₅₀	4.7 μM Compound: 1	Inhibition of growth in wild type MEF cells after 6 days Inhibition of growth in wild type MEF cells after 6 days	[PMID: 22607231]
MEF	IC₅₀	8 μM Compound: 1	Inhibition of growth in TSC2-deficient MEF cells after 6 days Inhibition of growth in TSC2-deficient MEF cells after 6 days	[PMID: 22607231]
PC-3	IC₅₀	24 μM Compound: 1b, PEITC	Cytotoxicity against human PC-3 cells after 72 hrs by MTS assay Cytotoxicity against human PC-3 cells after 72 hrs by MTS assay	[PMID: 19053750]
T47D	IC₅₀	9.7 μM Compound: B	Antiproliferative activity against human T47D cells after 72 hrs by SRB assay Antiproliferative activity against human T47D cells after 72 hrs by SRB assay	[PMID: 21704523]
T98G	IC₅₀	> 100 μM Compound: 1b, PEITC	Cytotoxicity against human T98G cells after 72 hrs by MTS assay Cytotoxicity against human T98G cells after 72 hrs by MTS assay	[PMID: 19053750]
UACC-903	IC₅₀	12 μM Compound: 1b, PEITC	Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay	[PMID: 19053750]

分子量

163.24

Formula

C₉H₉NS

CAS 号

2257-09-2

性状

液体（密度：1.094 g/cm³）

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (612.59 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.1259 mL	30.6297 mL	61.2595 mL
5 mM	1.2252 mL	6.1259 mL	12.2519 mL
10 mM	0.6126 mL	3.0630 mL	6.1259 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.31 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (15.31 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 98.04%

选择批次：

Data Sheet (619 KB) SDS (419 KB)

COA (189 KB) HNMR (225 KB) RP-HPLC (196 KB)

产品使用指南 (1538 KB)

参考文献

[1]. B. J. Smith, et al. In vitro inhibition of soil microorganisms by 2-phenylethyl isothiocyanate. Plant Pathology. 4 October 2002;51(5):585-593.

[2]. Zhang M, et al. 2-Phenylethyl Isothiocyanate Exerts Antifungal Activity against Alternaria alternata by Affecting Membrane Integrity and Mycotoxin Production. Toxins (Basel). 2020 Feb 15;12(2):124. [Content Brief]

2-Phenylethyl isothiocyanate 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.1259 mL	30.6297 mL	61.2595 mL	153.1487 mL
	5 mM	1.2252 mL	6.1259 mL	12.2519 mL	30.6297 mL
	10 mM	0.6126 mL	3.0630 mL	6.1259 mL	15.3149 mL
	15 mM	0.4084 mL	2.0420 mL	4.0840 mL	10.2099 mL
	20 mM	0.3063 mL	1.5315 mL	3.0630 mL	7.6574 mL
	25 mM	0.2450 mL	1.2252 mL	2.4504 mL	6.1259 mL
	30 mM	0.2042 mL	1.0210 mL	2.0420 mL	5.1050 mL
	40 mM	0.1531 mL	0.7657 mL	1.5315 mL	3.8287 mL
	50 mM	0.1225 mL	0.6126 mL	1.2252 mL	3.0630 mL
	60 mM	0.1021 mL	0.5105 mL	1.0210 mL	2.5525 mL
	80 mM	0.0766 mL	0.3829 mL	0.7657 mL	1.9144 mL
	100 mM	0.0613 mL	0.3063 mL	0.6126 mL	1.5315 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Phenylethyl isothiocyanate2257-09-22-PE ITCFungalsoil microorganismsblack spotAlternaria alternateantifungalfungioomycetesInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

2-Phenylethyl isothiocyanate (Synonyms: 2-PE ITC)

Customer Review

Other Forms of 2-Phenylethyl isothiocyanate: