3,7-Dihydroxyflavone  (Synonyms: Resogalangin)

3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC₅₀=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm^[1][2].

3,7-Dihydroxyflavone 和 HSA 的荧光实验，可以在甲醇中制备 3,7-Dihydroxyflavone 储备液，最终甲醇浓度低于 4% (v/v)。注意用 NaOH 或 H₃PO₄ 溶液将磷酸盐缓冲溶液的 pH 值调节至 3.5 和 7.4。使用 NaCl 溶液将溶液的离子强度保持在 0.1 M。实验温度为 25°C^[1]。
3,7-Dihydroxyflavone 的异戊烯基衍生物可抑制肿瘤细胞生长、增殖，诱导细胞凋亡^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

254.24

C₁₅H₁₀O₄

492-00-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ma J, et al. Spectroscopic investigation on the interaction of 3,7-dihydroxyflavone with different isomers of human serum albumin. Food Chem. 2012 May 1;132(1):663-70.  [Content Brief]

  [2]. Neves MP, et al. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Eur J Med Chem. 2011 Jun;46(6):2562-74.  [Content Brief]