2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. 4-Methyl erlotinib

4-Methyl erlotinib  (Synonyms: 4-甲基埃罗替尼)

目录号: HY-129510
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摩尔计算器

4-Methyl erlotinib，是一种强效且选择性的表皮生长因子受体 (EGFR) 酪氨酸激酶抑制剂。4-Methyl erlotinib 通过降低 EGFr 特异性酪氨酸磷酸化有效抑制 EGF 介导的肿瘤细胞有丝分裂。在使用人类肿瘤移植小鼠模型中，4-Methyl erlotinib 展示了显著且持续的抑制 EGFr 磷酸酪氨酸水平，导致 EGFr 依赖型人类癌症的显著生长抑制。

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4-Methyl erlotinib Chemical Structure

4-Methyl erlotinib Chemical Structure

CAS No. : 1346601-52-2

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4-Methyl erlotinib 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers[1].

分子量

407.46

Formula

C23H25N3O4
CAS 号
中文名称

4-甲基埃罗替尼
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-Methyl erlotinib 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Methyl erlotinib1346601-52-24-甲基埃罗替尼EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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