2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. 7α,15-Dihydroxydehydroabietic acid

7α,15-Dihydroxydehydroabietic acid  (Synonyms: 7α,15-二羟基脱氢松香酸)

目录号: HY-N7830
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7α,15-Dihydroxydehydroabietic acid 是一种天然的枞烷类二萜类化合物，具有抗血管生成作用。

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7α,15-Dihydroxydehydroabietic acid Chemical Structure

7α,15-Dihydroxydehydroabietic acid Chemical Structure

CAS No. : 155205-64-4

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7α,15-Dihydroxydehydroabietic acid 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects[1].

体外研究
(In Vitro)

7α,15-Dihydroxydehydroabietic acid（3.125-100 μM；24 小时）显着降低 HUVEC 细胞活力[1]。
7α,15-Dihydroxydehydroabietic acid (3.125-6.25 μM; 24 小时) 显着抑制 HUVEC 中血管生成的促进作用。7α,15-Dihydroxydehydroabietic acid 通过下调 VEGF、p-Akt 和 p-ERK 信号通路抑制血管生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

7α,15-Dihydroxydehydroabietic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 3.125 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
Incubation Time: 24 hours
Result: Significantly decreased HUVEC cell viability.

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 3.125 μM, 6.25 μM
Incubation Time: 24 hours
Result: Human umbilical vein endothelial cells (HUVECs)[1] 3.125 μM, 6.25 μM 24 hours Showed downregulation of VEGF, p-Akt and p-ERK in HUVECs.
分子量

332.43

Formula

C20H28O4
CAS 号
中文名称

7α,15-二羟基脱氢松香酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7α,15-Dihydroxydehydroabietic acid 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

7α,15-Dihydroxydehydroabietic acid155205-64-47α,15-二羟基脱氢松香酸ERKExtracellular signal regulated kinasesVEGFp-Aktp-ERKabietane-type diterpenoidantiangiogenic effectsInhibitorinhibitorinhibit

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